簡要描述：CRANAD 2 （1193447-34-5）is a near-infrared probe that binds to Aβ40 aggregates and elicits an emission blue shift. It was shown to bind to plaques in APP-PS1 transgenic mice, in vitro.
產(chǎn)品型號：1193447-34-5廠商性質(zhì)：生產(chǎn)廠家更新時間：2023-12-04訪 問 量：1243Biochem/physiol Actions
CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.
CAS:1193447-34-5
中文名稱：CRANAD-2
英文名稱：CRANAD-2
英文別名：(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron
CAS號：1193447-34-5
分子式：C23H25BF2N2O2
分子量：410.26500
精確質(zhì)量：410.19800
PSA：32.78000
LogP：4.93870
外觀與性狀：深藍色或黑色粉末
可溶性：DMSO: soluble 0.2 mg/mL, clear (warmed)
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